diff --git a/openapi_core/contrib/django/requests.py b/openapi_core/contrib/django/requests.py
index 67584239..22de94e9 100644
--- a/openapi_core/contrib/django/requests.py
+++ b/openapi_core/contrib/django/requests.py
@@ -30,6 +30,8 @@ class DjangoOpenAPIRequest:
     path_regex = re.compile(PATH_PARAMETER_PATTERN)
 
     def __init__(self, request: HttpRequest):
+        if not isinstance(request, HttpRequest):
+            raise TypeError(f"'request' argument is not type of {HttpRequest}")
         self.request = request
 
         path = (
diff --git a/openapi_core/contrib/django/responses.py b/openapi_core/contrib/django/responses.py
index 838eff06..c1c09256 100644
--- a/openapi_core/contrib/django/responses.py
+++ b/openapi_core/contrib/django/responses.py
@@ -5,6 +5,10 @@
 
 class DjangoOpenAPIResponse:
     def __init__(self, response: HttpResponse):
+        if not isinstance(response, HttpResponse):
+            raise TypeError(
+                f"'response' argument is not type of {HttpResponse}"
+            )
         self.response = response
 
     @property
diff --git a/openapi_core/contrib/falcon/requests.py b/openapi_core/contrib/falcon/requests.py
index c078e8bf..bb23586e 100644
--- a/openapi_core/contrib/falcon/requests.py
+++ b/openapi_core/contrib/falcon/requests.py
@@ -18,6 +18,8 @@ def __init__(
         request: Request,
         default_when_empty: Optional[Dict[Any, Any]] = None,
     ):
+        if not isinstance(request, Request):
+            raise TypeError(f"'request' argument is not type of {Request}")
         self.request = request
         if default_when_empty is None:
             default_when_empty = {}
diff --git a/openapi_core/contrib/falcon/responses.py b/openapi_core/contrib/falcon/responses.py
index 75168557..284c64ba 100644
--- a/openapi_core/contrib/falcon/responses.py
+++ b/openapi_core/contrib/falcon/responses.py
@@ -5,6 +5,8 @@
 
 class FalconOpenAPIResponse:
     def __init__(self, response: Response):
+        if not isinstance(response, Response):
+            raise TypeError(f"'response' argument is not type of {Response}")
         self.response = response
 
     @property
diff --git a/openapi_core/contrib/flask/requests.py b/openapi_core/contrib/flask/requests.py
index cb1e658c..656ad9b6 100644
--- a/openapi_core/contrib/flask/requests.py
+++ b/openapi_core/contrib/flask/requests.py
@@ -9,6 +9,8 @@
 
 class FlaskOpenAPIRequest(WerkzeugOpenAPIRequest):
     def __init__(self, request: Request):
+        if not isinstance(request, Request):
+            raise TypeError(f"'request' argument is not type of {Request}")
         self.request: Request = request
 
         self.parameters = RequestParameters(
diff --git a/openapi_core/contrib/requests/requests.py b/openapi_core/contrib/requests/requests.py
index f666c939..d543fec9 100644
--- a/openapi_core/contrib/requests/requests.py
+++ b/openapi_core/contrib/requests/requests.py
@@ -23,6 +23,11 @@ class RequestsOpenAPIRequest:
     """
 
     def __init__(self, request: Union[Request, PreparedRequest]):
+        if not isinstance(request, (Request, PreparedRequest)):
+            raise TypeError(
+                "'request' argument is not type of "
+                f"{Request} or {PreparedRequest}"
+            )
         if isinstance(request, Request):
             request = request.prepare()
 
diff --git a/openapi_core/contrib/requests/responses.py b/openapi_core/contrib/requests/responses.py
index 149012af..66343802 100644
--- a/openapi_core/contrib/requests/responses.py
+++ b/openapi_core/contrib/requests/responses.py
@@ -5,6 +5,8 @@
 
 class RequestsOpenAPIResponse:
     def __init__(self, response: Response):
+        if not isinstance(response, Response):
+            raise TypeError(f"'response' argument is not type of {Response}")
         self.response = response
 
     @property
diff --git a/openapi_core/contrib/starlette/requests.py b/openapi_core/contrib/starlette/requests.py
index 5ac96d7d..4073003d 100644
--- a/openapi_core/contrib/starlette/requests.py
+++ b/openapi_core/contrib/starlette/requests.py
@@ -9,6 +9,8 @@
 
 class StarletteOpenAPIRequest:
     def __init__(self, request: Request):
+        if not isinstance(request, Request):
+            raise TypeError(f"'request' argument is not type of {Request}")
         self.request = request
 
         self.parameters = RequestParameters(
diff --git a/openapi_core/contrib/starlette/responses.py b/openapi_core/contrib/starlette/responses.py
index 8d042e8d..49be986f 100644
--- a/openapi_core/contrib/starlette/responses.py
+++ b/openapi_core/contrib/starlette/responses.py
@@ -5,6 +5,8 @@
 
 class StarletteOpenAPIResponse:
     def __init__(self, response: Response):
+        if not isinstance(response, Response):
+            raise TypeError(f"'response' argument is not type of {Response}")
         self.response = response
 
     @property
diff --git a/openapi_core/contrib/werkzeug/requests.py b/openapi_core/contrib/werkzeug/requests.py
index 6c0c30c9..cbfa3e81 100644
--- a/openapi_core/contrib/werkzeug/requests.py
+++ b/openapi_core/contrib/werkzeug/requests.py
@@ -17,6 +17,8 @@ class WerkzeugOpenAPIRequest:
     path_regex = re.compile(PATH_PARAMETER_PATTERN)
 
     def __init__(self, request: Request):
+        if not isinstance(request, Request):
+            raise TypeError(f"'request' argument is not type of {Request}")
         self.request = request
 
         self.parameters = RequestParameters(
diff --git a/openapi_core/contrib/werkzeug/responses.py b/openapi_core/contrib/werkzeug/responses.py
index 23327e52..c3fc9501 100644
--- a/openapi_core/contrib/werkzeug/responses.py
+++ b/openapi_core/contrib/werkzeug/responses.py
@@ -5,6 +5,8 @@
 
 class WerkzeugOpenAPIResponse:
     def __init__(self, response: Response):
+        if not isinstance(response, Response):
+            raise TypeError(f"'response' argument is not type of {Response}")
         self.response = response
 
     @property
diff --git a/tests/unit/contrib/django/test_django.py b/tests/unit/contrib/django/test_django.py
index 25003615..fb4d0316 100644
--- a/tests/unit/contrib/django/test_django.py
+++ b/tests/unit/contrib/django/test_django.py
@@ -63,6 +63,10 @@ def create(content=b"", status_code=None):
 
 
 class TestDjangoOpenAPIRequest(BaseTestDjango):
+    def test_type_invalid(self):
+        with pytest.raises(TypeError):
+            DjangoOpenAPIRequest(None)
+
     def test_no_resolver(self, request_factory):
         data = {"test1": "test2"}
         request = request_factory.get("/admin/", data)
@@ -168,6 +172,10 @@ def test_drf_default_value_pattern(self, request_factory):
 
 
 class TestDjangoOpenAPIResponse(BaseTestDjango):
+    def test_type_invalid(self):
+        with pytest.raises(TypeError):
+            DjangoOpenAPIResponse(None)
+
     def test_stream_response(self, response_factory):
         response = response_factory()
         response.writelines(["foo\n", "bar\n", "baz\n"])
diff --git a/tests/unit/contrib/flask/test_flask_requests.py b/tests/unit/contrib/flask/test_flask_requests.py
index 08d7828a..80f92181 100644
--- a/tests/unit/contrib/flask/test_flask_requests.py
+++ b/tests/unit/contrib/flask/test_flask_requests.py
@@ -1,5 +1,6 @@
 from urllib.parse import urljoin
 
+import pytest
 from werkzeug.datastructures import Headers
 from werkzeug.datastructures import ImmutableMultiDict
 
@@ -8,6 +9,10 @@
 
 
 class TestFlaskOpenAPIRequest:
+    def test_type_invalid(self):
+        with pytest.raises(TypeError):
+            FlaskOpenAPIRequest(None)
+
     def test_simple(self, request_factory, request):
         request = request_factory("GET", "/", subdomain="www")
 
diff --git a/tests/unit/contrib/flask/test_flask_responses.py b/tests/unit/contrib/flask/test_flask_responses.py
index 6b9c30f6..d907bd32 100644
--- a/tests/unit/contrib/flask/test_flask_responses.py
+++ b/tests/unit/contrib/flask/test_flask_responses.py
@@ -1,7 +1,13 @@
+import pytest
+
 from openapi_core.contrib.flask import FlaskOpenAPIResponse
 
 
 class TestFlaskOpenAPIResponse:
+    def test_type_invalid(self):
+        with pytest.raises(TypeError):
+            FlaskOpenAPIResponse(None)
+
     def test_invalid_server(self, response_factory):
         data = "Not Found"
         status_code = 404
diff --git a/tests/unit/contrib/requests/test_requests_requests.py b/tests/unit/contrib/requests/test_requests_requests.py
index 4e444d15..6d3a7982 100644
--- a/tests/unit/contrib/requests/test_requests_requests.py
+++ b/tests/unit/contrib/requests/test_requests_requests.py
@@ -1,3 +1,4 @@
+import pytest
 from werkzeug.datastructures import Headers
 from werkzeug.datastructures import ImmutableMultiDict
 
@@ -6,6 +7,10 @@
 
 
 class TestRequestsOpenAPIRequest:
+    def test_type_invalid(self):
+        with pytest.raises(TypeError):
+            RequestsOpenAPIRequest(None)
+
     def test_simple(self, request_factory, request):
         request = request_factory("GET", "/", subdomain="www")
 
diff --git a/tests/unit/contrib/requests/test_requests_responses.py b/tests/unit/contrib/requests/test_requests_responses.py
index 62da483f..f5b79256 100644
--- a/tests/unit/contrib/requests/test_requests_responses.py
+++ b/tests/unit/contrib/requests/test_requests_responses.py
@@ -1,7 +1,13 @@
+import pytest
+
 from openapi_core.contrib.requests import RequestsOpenAPIResponse
 
 
 class TestRequestsOpenAPIResponse:
+    def test_type_invalid(self):
+        with pytest.raises(TypeError):
+            RequestsOpenAPIResponse(None)
+
     def test_invalid_server(self, response_factory):
         data = "Not Found"
         status_code = 404