diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index 421162a07f8d5..ef22e9dfd73e6 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -35405,7 +35405,7 @@ namespace ts {
                                         superCallStatement = statement;
                                         break;
                                     }
-                                    if (!isPrologueDirective(statement) && nodeImmediatelyReferencesSuperOrThis(statement)) {
+                                    if (nodeImmediatelyReferencesSuperOrThis(statement)) {
                                         break;
                                     }
                                 }
diff --git a/src/compiler/transformers/ts.ts b/src/compiler/transformers/ts.ts
index 994601a426563..bcb92d9594a8a 100644
--- a/src/compiler/transformers/ts.ts
+++ b/src/compiler/transformers/ts.ts
@@ -1938,14 +1938,14 @@ namespace ts {
 
             resumeLexicalEnvironment();
 
-            const indexAfterLastPrologueStatement = factory.copyPrologue(body.statements, statements, /*ensureUseStrict*/ false, visitor);
-            const superStatementIndex = findSuperStatementIndex(body.statements, indexAfterLastPrologueStatement);
+            const prologueStatementCount = factory.copyPrologue(body.statements, statements, /*ensureUseStrict*/ false, visitor);
+            const superStatementIndex = findSuperStatementIndex(body.statements, prologueStatementCount);
 
             // If there was a super call, visit existing statements up to and including it
             if (superStatementIndex >= 0) {
                 addRange(
                     statements,
-                    visitNodes(body.statements, visitor, isStatement, indexAfterLastPrologueStatement, superStatementIndex + 1 - indexAfterLastPrologueStatement),
+                    visitNodes(body.statements, visitor, isStatement, prologueStatementCount, superStatementIndex + 1 - prologueStatementCount),
                 );
             }
 
@@ -1967,13 +1967,17 @@ namespace ts {
             if (superStatementIndex >= 0) {
                 addRange(statements, parameterPropertyAssignments);
             }
-            // Since there was no super() call, parameter properties are the first statements in the constructor
+            // Since there was no super() call, parameter properties are the first statements in the constructor after any prologue statements
             else {
-                statements = addRange(parameterPropertyAssignments, statements);
+                statements = [
+                    ...statements.slice(0, prologueStatementCount),
+                    ...parameterPropertyAssignments,
+                    ...statements.slice(prologueStatementCount),
+                ];
             }
 
-            // Add remaining statements from the body, skipping the super() call if it was found
-            addRange(statements, visitNodes(body.statements, visitor, isStatement, superStatementIndex + 1));
+            // Add remaining statements from the body, skipping the super() call if it was found and any (already added) prologue statements
+            addRange(statements, visitNodes(body.statements, visitor, isStatement, superStatementIndex + 1 + prologueStatementCount));
 
             // End the lexical environment.
             statements = factory.mergeLexicalEnvironment(statements, endLexicalEnvironment());
diff --git a/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.js b/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.js
new file mode 100644
index 0000000000000..d952cf8ba177c
--- /dev/null
+++ b/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.js
@@ -0,0 +1,104 @@
+//// [parameterPropertyInConstructorWithPrologues.ts]
+// https://github.com/microsoft/TypeScript/issues/48671
+
+class Foo1 {
+  constructor(private A: string) {
+    "ngInject1";
+  }
+}
+
+class Foo2 {
+  constructor(private A: string, private B: string) {
+    "ngInject1";
+    "ngInject2";
+  }
+}
+
+class Foo3 {
+  constructor(private A: string, private B: string, private C: string) {
+    "ngInject1";
+    "ngInject2";
+  }
+}
+
+class Foo4 {
+  constructor(private A: string) {
+    "ngInject1";
+    console.log("hi");
+  }
+}
+
+class Foo5 {
+  constructor(private A: string, private B: string) {
+    "ngInject1";
+    "ngInject2";
+    console.log("hi");
+  }
+}
+
+class Foo6 {
+  constructor(private A: string, private B: string, private C: string) {
+    "ngInject1";
+    "ngInject2";
+    console.log("hi");
+  }
+}
+
+
+//// [parameterPropertyInConstructorWithPrologues.js]
+// https://github.com/microsoft/TypeScript/issues/48671
+var Foo1 = /** @class */ (function () {
+    function Foo1(A) {
+        "ngInject1";
+        this.A = A;
+    }
+    return Foo1;
+}());
+var Foo2 = /** @class */ (function () {
+    function Foo2(A, B) {
+        "ngInject1";
+        "ngInject2";
+        this.A = A;
+        this.B = B;
+    }
+    return Foo2;
+}());
+var Foo3 = /** @class */ (function () {
+    function Foo3(A, B, C) {
+        "ngInject1";
+        "ngInject2";
+        this.A = A;
+        this.B = B;
+        this.C = C;
+    }
+    return Foo3;
+}());
+var Foo4 = /** @class */ (function () {
+    function Foo4(A) {
+        "ngInject1";
+        this.A = A;
+        console.log("hi");
+    }
+    return Foo4;
+}());
+var Foo5 = /** @class */ (function () {
+    function Foo5(A, B) {
+        "ngInject1";
+        "ngInject2";
+        this.A = A;
+        this.B = B;
+        console.log("hi");
+    }
+    return Foo5;
+}());
+var Foo6 = /** @class */ (function () {
+    function Foo6(A, B, C) {
+        "ngInject1";
+        "ngInject2";
+        this.A = A;
+        this.B = B;
+        this.C = C;
+        console.log("hi");
+    }
+    return Foo6;
+}());
diff --git a/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.symbols b/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.symbols
new file mode 100644
index 0000000000000..582bfd762d229
--- /dev/null
+++ b/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.symbols
@@ -0,0 +1,85 @@
+=== tests/cases/compiler/parameterPropertyInConstructorWithPrologues.ts ===
+// https://github.com/microsoft/TypeScript/issues/48671
+
+class Foo1 {
+>Foo1 : Symbol(Foo1, Decl(parameterPropertyInConstructorWithPrologues.ts, 0, 0))
+
+  constructor(private A: string) {
+>A : Symbol(Foo1.A, Decl(parameterPropertyInConstructorWithPrologues.ts, 3, 14))
+
+    "ngInject1";
+  }
+}
+
+class Foo2 {
+>Foo2 : Symbol(Foo2, Decl(parameterPropertyInConstructorWithPrologues.ts, 6, 1))
+
+  constructor(private A: string, private B: string) {
+>A : Symbol(Foo2.A, Decl(parameterPropertyInConstructorWithPrologues.ts, 9, 14))
+>B : Symbol(Foo2.B, Decl(parameterPropertyInConstructorWithPrologues.ts, 9, 32))
+
+    "ngInject1";
+    "ngInject2";
+  }
+}
+
+class Foo3 {
+>Foo3 : Symbol(Foo3, Decl(parameterPropertyInConstructorWithPrologues.ts, 13, 1))
+
+  constructor(private A: string, private B: string, private C: string) {
+>A : Symbol(Foo3.A, Decl(parameterPropertyInConstructorWithPrologues.ts, 16, 14))
+>B : Symbol(Foo3.B, Decl(parameterPropertyInConstructorWithPrologues.ts, 16, 32))
+>C : Symbol(Foo3.C, Decl(parameterPropertyInConstructorWithPrologues.ts, 16, 51))
+
+    "ngInject1";
+    "ngInject2";
+  }
+}
+
+class Foo4 {
+>Foo4 : Symbol(Foo4, Decl(parameterPropertyInConstructorWithPrologues.ts, 20, 1))
+
+  constructor(private A: string) {
+>A : Symbol(Foo4.A, Decl(parameterPropertyInConstructorWithPrologues.ts, 23, 14))
+
+    "ngInject1";
+    console.log("hi");
+>console.log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>console : Symbol(console, Decl(lib.dom.d.ts, --, --))
+>log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+  }
+}
+
+class Foo5 {
+>Foo5 : Symbol(Foo5, Decl(parameterPropertyInConstructorWithPrologues.ts, 27, 1))
+
+  constructor(private A: string, private B: string) {
+>A : Symbol(Foo5.A, Decl(parameterPropertyInConstructorWithPrologues.ts, 30, 14))
+>B : Symbol(Foo5.B, Decl(parameterPropertyInConstructorWithPrologues.ts, 30, 32))
+
+    "ngInject1";
+    "ngInject2";
+    console.log("hi");
+>console.log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>console : Symbol(console, Decl(lib.dom.d.ts, --, --))
+>log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+  }
+}
+
+class Foo6 {
+>Foo6 : Symbol(Foo6, Decl(parameterPropertyInConstructorWithPrologues.ts, 35, 1))
+
+  constructor(private A: string, private B: string, private C: string) {
+>A : Symbol(Foo6.A, Decl(parameterPropertyInConstructorWithPrologues.ts, 38, 14))
+>B : Symbol(Foo6.B, Decl(parameterPropertyInConstructorWithPrologues.ts, 38, 32))
+>C : Symbol(Foo6.C, Decl(parameterPropertyInConstructorWithPrologues.ts, 38, 51))
+
+    "ngInject1";
+    "ngInject2";
+    console.log("hi");
+>console.log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>console : Symbol(console, Decl(lib.dom.d.ts, --, --))
+>log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+  }
+}
+
diff --git a/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.types b/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.types
new file mode 100644
index 0000000000000..2f676ee39ee50
--- /dev/null
+++ b/tests/baselines/reference/parameterPropertyInConstructorWithPrologues.types
@@ -0,0 +1,108 @@
+=== tests/cases/compiler/parameterPropertyInConstructorWithPrologues.ts ===
+// https://github.com/microsoft/TypeScript/issues/48671
+
+class Foo1 {
+>Foo1 : Foo1
+
+  constructor(private A: string) {
+>A : string
+
+    "ngInject1";
+>"ngInject1" : "ngInject1"
+  }
+}
+
+class Foo2 {
+>Foo2 : Foo2
+
+  constructor(private A: string, private B: string) {
+>A : string
+>B : string
+
+    "ngInject1";
+>"ngInject1" : "ngInject1"
+
+    "ngInject2";
+>"ngInject2" : "ngInject2"
+  }
+}
+
+class Foo3 {
+>Foo3 : Foo3
+
+  constructor(private A: string, private B: string, private C: string) {
+>A : string
+>B : string
+>C : string
+
+    "ngInject1";
+>"ngInject1" : "ngInject1"
+
+    "ngInject2";
+>"ngInject2" : "ngInject2"
+  }
+}
+
+class Foo4 {
+>Foo4 : Foo4
+
+  constructor(private A: string) {
+>A : string
+
+    "ngInject1";
+>"ngInject1" : "ngInject1"
+
+    console.log("hi");
+>console.log("hi") : void
+>console.log : (...data: any[]) => void
+>console : Console
+>log : (...data: any[]) => void
+>"hi" : "hi"
+  }
+}
+
+class Foo5 {
+>Foo5 : Foo5
+
+  constructor(private A: string, private B: string) {
+>A : string
+>B : string
+
+    "ngInject1";
+>"ngInject1" : "ngInject1"
+
+    "ngInject2";
+>"ngInject2" : "ngInject2"
+
+    console.log("hi");
+>console.log("hi") : void
+>console.log : (...data: any[]) => void
+>console : Console
+>log : (...data: any[]) => void
+>"hi" : "hi"
+  }
+}
+
+class Foo6 {
+>Foo6 : Foo6
+
+  constructor(private A: string, private B: string, private C: string) {
+>A : string
+>B : string
+>C : string
+
+    "ngInject1";
+>"ngInject1" : "ngInject1"
+
+    "ngInject2";
+>"ngInject2" : "ngInject2"
+
+    console.log("hi");
+>console.log("hi") : void
+>console.log : (...data: any[]) => void
+>console : Console
+>log : (...data: any[]) => void
+>"hi" : "hi"
+  }
+}
+
diff --git a/tests/cases/compiler/parameterPropertyInConstructorWithPrologues.ts b/tests/cases/compiler/parameterPropertyInConstructorWithPrologues.ts
new file mode 100644
index 0000000000000..aa6acde1ae90c
--- /dev/null
+++ b/tests/cases/compiler/parameterPropertyInConstructorWithPrologues.ts
@@ -0,0 +1,44 @@
+// https://github.com/microsoft/TypeScript/issues/48671
+
+class Foo1 {
+  constructor(private A: string) {
+    "ngInject1";
+  }
+}
+
+class Foo2 {
+  constructor(private A: string, private B: string) {
+    "ngInject1";
+    "ngInject2";
+  }
+}
+
+class Foo3 {
+  constructor(private A: string, private B: string, private C: string) {
+    "ngInject1";
+    "ngInject2";
+  }
+}
+
+class Foo4 {
+  constructor(private A: string) {
+    "ngInject1";
+    console.log("hi");
+  }
+}
+
+class Foo5 {
+  constructor(private A: string, private B: string) {
+    "ngInject1";
+    "ngInject2";
+    console.log("hi");
+  }
+}
+
+class Foo6 {
+  constructor(private A: string, private B: string, private C: string) {
+    "ngInject1";
+    "ngInject2";
+    console.log("hi");
+  }
+}